The human population are increasingly exposed to various chemicals whose beneficial or deleterious properties often remain unexplored. The rising public concern about hazardous substances existing in foods and consumer products has forced legislators to tighten chemical management policy that requires extensive toxicity testing. However, assessment of chemical toxicity is a challenging task, especially in terms of reliability and efficiency. Ethical issues over the use of animal testing also add further complication to the task.
The zebrafish (Danio rerio) embryo is an emerging model system for chemical testing that is attracting scientific and legal attention. Its advantages including rapid development, high availability, and easy observation have made the model amenable to high-throughput assays. Moreover, as a complex and independent organism retaining the “non-animal” status, the zebrafish embryo is the ideal vertebrate testing model.
Inspired by the promising applications of the zebrafish embryo model in toxicology research, with the objectives of developing analysis techniques and applying them in testing of different small molecular compounds, we decided to carry out the project “Toxicity assessment of small molecules using the zebrafish as a model system”.
Tải về miễn phí bản đầy đủ luận văn tại địa chỉ: